Treatment of Severe Hyperglycemia in Extremely Preterm Infants Using Continuous Subcutaneous Insulin Therapy

What is already known on this topic?Hyperglycemia is common in preterm infants and can affect long-term outcomes, especially regarding the neurological outcome.However, there are no treatment guidelines and there are a lot of controversies.Insulin is mostly administered via continuous intravenous infusion in preterm infants.Continuous subcutaneous insulin infusion in preterm infants is only described in a few case reports and clinical research papers. What this study adds?This study adds clinical expertise in the application of CSII in extremely preterm infants.The comparison of CSII and intravenously given Insulin in preterm infants allows to draw conclusions on the feasibility and dose control of CSII in preterm infants.To our knowledge it is the largest, described cohort of extremely preterm infants receiving CSII.