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August 1, 1991Diabetes Care

Randomized Trial Comparing Continuous Subcutaneous Insulin Infusion and Conventional Insulin Therapy in Type II Diabetic Patients Poorly Controlled With Sulfonylureas

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To compare the effectiveness of continuous subcutaneous insulin infusion and conventional insulin therapy in poorly controlled type II diabetes patients.
Randomized trial with 25 patients aged 40-65 years, poorly controlled with sulfonylureas
10 patients treated with continuous subcutaneous insulin infusion and 10 with conventional insulin therapy
Outpatient treatment with twice-daily injections for CIT or basal and prandial boluses for CSII.
8 of 10 CSII-treated patients achieved satisfactory glycemic control (HbA1 less than 50 mmol hydroxymethylfurfural/mol Hb) compared to 3 of 10 in the CIT group (P less than 0.05)
Glycosylated hemoglobin improved in both groups (P less than 0.01)
Patients' satisfaction with treatment improved (P less than 0.02) and significant changes regarding diabetes beliefs in CSII-treated patients (P less than 0.05).

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Randomized trial compares glycemic control in type II diabetic patients treated with CSII and CIT, indicating CSII may be more effective.

Jennings et al. (1991) studied this question.

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