Discrimination of Optical Properties of Healthy and Cancerous Ovarian Tissue

In this work, the optical properties of ovarian tissue of cats with histologically confirmed diagnoses: leimyosarcoma, stromal sarcoma, serous carcinoma, granulosa carcinoma, follicular phase (healthy) and luteal phase (healthy), in the optical range from 450 to 800 nm were experimentally studied. Based on the measured spectra of diffuse reflectance, total transmittance and collimated transmittance spectra, absorption and scattering coefficients were determined using the inverse adding-doubling method, as well as the spectral dependence of the scattering anisotropy factor and the depth of radiation penetration into ovarian tissue in normal conditions and in various types of cancer. The difference in the scattering and absorption properties of healthy and cancer ovaries can serve as an important and promising marker of pathology in the early stages in clinical applications, as well as in the search and prove of diagnostically significant criteria for assessing the metabolic state of tissues.