Immunohistochemical Expression of CD10 in Invasive Breast Carcinoma: A clinico-Pathologic Study

Background: Prior research has established a correlation between CD10 and the biological aggressiveness exhibited by many human malignancies. Objective: This research aimed to assess CD10 expression in invasive breast carcinoma and its correlation with clinic-pathological characteristics. Patients and methods: This descriptive cross-sectional study included 60 cases diagnosed as invasive breast carcinoma, aged between 30 and 70 years, were submitted to the histopathology lab at Al-Zahraa University Hospital. By using immunohistochemical method to show expression of CD10 in our cases of invasive breast carcinoma. Results: In 78.4% of the cases, the expression of CD10 was detected in cytoplasm of stromal fusiform cells (46.7% as weak expression and31.7% as strong expression).The incidence of stromal CD10 positivity was considerably higher in tumors that had metastases to lymph nodes (p ≤ 0.05), a notable quality with increase tumor differentiation(p ≤0.05), and tumor size (p ≤ 0.05).Additionally correlated with estrogen receptor (ER) expression (p ≤ 0.05), progesterone receptor (PR) expression (p ≤ 0.05), and Ki-67 expression (p ≤ 0.05). Conclusions: These outcomes revealed the function of stromal CD10 expression in the advancement and spread of breast cancer and may participate in the progression of novel therapies for breast carcinoma.