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June 21, 2024Frontiers in Bioscience-LandmarkOpen Access

MGST1 May Regulate the Ferroptosis of the Annulus Fibrosus of Intervertebral Disc: Bioinformatic Integrated Analysis and Validation

Zhenxin Huo Dawei Li Kaihui Zhang Bingshan Yan Tongxing Zhang Zhenhua Li Shengbo Huang Yue Liu Baoshan Xu

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Abstract

The objective of this research was to identify differentially expressed genes (DEGs) related to ferroptosis in the annulus fibrosus (AF) during intervertebral disc degeneration (IDD).

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Cite This Study

Huo et al. (2024) studied this question.

synapsesocial.com/papers/68e63c23b6db6435875ce7c0 https://doi.org/10.31083/j.fbl2906224

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Identification and validation of ferroptosis-related biomarkers in intervertebral disc degeneration2024 · 8 citations
2Integrated bioinformatics analysis of ferroptosis-related gene signature in inflammation and immunity in intervertebral disc degeneration2024 · 2 citations
3Identification and Functional Validation of ACSL1 as a Biomarker Regulating Ferroptosis in Nucleus Pulposus Cell2024
4STAT3/POSTN/GSTP1/JNK Axis Orchestrates Ferroptosis in Nucleus Pulposus Cells: A Potential Therapeutic Target for Intervertebral Disc DegenerationOriginal Research · 2026
5The protective up-regulation of metallothionein-2A in intervertebral disc degeneration inhibits nucleus pulposus cell ferroptosis through activation of the PI3K/AKT/mTOR pathwayOriginal Research · 2026 · 2 citations