Role of Beta Catenin, GAB1, YAP1 and P53 Antibodies in the Molecular Classification of Medulloblastoma: Analysis of a Series of 68 Cases

Medulloblastoma can occur at any age, but most commonly occurs during childhood. It is the second most common CNS malignancy in children. It’s must now be classified according to a combination of molecular and histopathological features. There are 4 genetically defined groups and 4 histologically defined groups: Genetically defined: WNT activated, SHH activated (either TP53 mutant or TP53 wild type), non-WNT / non-SHH, Histologically defined: classic, desmoplastic / nodular, medulloblastoma with extensive nodularity and large cell / anaplastic medulloblastoma. We report a retrospective study, spread over 68 months covering 21 cases Colligated at the CHU Mohammed VI of Marrakech between January 2018 and August 2023.