The Effect of Vitamin E on Glucose Levels in Diabetic Mice

Objective To evaluate the blood glucose levels in diabetic mice treated with vitamin and those who were untreated. Methods It was an Experimental study. This study was conducted in the Anatomy Department of the Army Medical College, from November 2009 to November 2010 in cooperation with (NIH) National Institute of Health, Islamabad. Three groups of thirty mature female BALB/C mice were randomly selected. Group A acted as the study control. Streptozotocin (STZ) was administered intraperitoneally to Group B to cause diabetes. STZ was administered intravenously to Group C, and they had a diet high in Vitamin E (alphatocopherol). All Group's Serum glucose levels were monitored using a glucometer at the beginning of the trial, after 72 hours following STZ injection, and then after 12 weeks. Results There is a considerable change in blood glucose levels between the diabetic group (Group B) and a diabetic group treated with Vitamin E (Group C) respectively. When compared to experimental Group B, Group C's blood glucose level dropped significantly. Conclusion Vitamin E treatment for diabetic mice may have a significant impact on lowering blood glucose levels through the use of antioxidant therapy.