Studies have been conducted on the influence of various modes of ultrasound on the functional activity of peritoneal macrophages in nitro. It was found that the use of low-intensity broadband ultrasound (UMUS) significantly increases the cytotoxic and respiratory activity of macrophages compared to low-intensity pulsed ultrasound (LIPUS) and control. There was a significant increase in the level of endogenous peroxidase in the macrophage lysate, as well as a transition of macrophages from the M1 (pro-inflammatory) to M2 (anti-inflammatory) state when using UMUS.
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Kuzmenko et al. (2024) studied this question.
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