Effects of Fitoscar™ (dry extract of Stryphnodendron adstringens 50%) on the healing of acute wounds in Wistar rats

Several studies show the potential of Stryphnodendron adstringens (Mart.) Coville bark preparations in wound healing. A medicine called Fitoscar™ is based on this herbal medicine, which is commercially available and facilitates its acquisition by the patient. However, studies with Fitoscar™ are necessary to determine its effects during the healing processes. The aim of this study was to evaluate the effects of Fitoscar™ on different wound healing events induced in Wistar rats. Excisional wounds were experimentally induced in Wistar rats, divided into two groups: control: wound cleaning with warm 0.9% saline solution (39° to 40°C) and treated with Fitoscar™, subdivided into 04 subgroups, corresponding to 3, 7, 14 and 21 days of experimental period. Morphometric, macroscopic and microscopic analyzes were performed. Fitoscar™ influenced fibroblast migration and stimulated angiogenesis at days 3 and 7 respectively. While there was greater intensity of miofibroblasts at day 14. At 21 days, Fitoscar™ induced more crust and hypergranulation. While Fitoscar™ group presented lower percentage of wound closure on days 7 and 14, however all wounds healed completely in a similar time, 21 days. Fitoscar™ may favor wound healing, leading to fibroblast migration and angiogenesis during the inflammatory and proliferative phases in acute experimental wounds.