Active chromatin marks in MYCN-amplified neuroblastoma and repressive chromatin marks in neuroblastoma cells with long telomeres. ChromHMM states, all ChIP-Seq tracks and WGBS for MYCN-amplified O-PDX (SJNBL013763, A) and cell line (SKNBE2, B) showing active marks in the TERT locus. ChromHMM states, all ChIP-seq tracks and WGBS for ATRX-mutant, ALT-positive O-PDX (SJNBL030014, C) and cell line (SKNMM, D) showing repressive marks in the TERT locus. The color codes for different ChromHMM states are shown in E.
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Graham et al. (2024) studied this question.
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