Autism spectrum disorders along with other neurodevelopmental disorders, constitutes psychiatric conditions considered public health issues with a strong socioeconomic impact. The onset of autism is before the age of 3 and characterised by aberrant social interactions, communication problems with language deficits and restrictive and repetitive behaviors. The etiology of autism is not well understand, but both environmental and genetic factors may be involved probably in a interactional model type. The key symptoms of autism spectrum disorders have been intensively studied using genetic animal models and also the valproic acid (VPA)-induced model. The existence of such animal models of autism could allow for a rigorous evaluation of the effects produced by environmental factors on the behavioral expression of neuropathological deficits in VPA-treated animals.
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Ionescu et al. (2024) studied this question.
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