Recent progress in xenotransplantation using humanized pigs is reported for heart and kidney transplants. 1,2The first xenotransplant of a liver into a living person was also performed in China very recently. 3dvancement in this organ transplant field is remarkable, but the earlier consequences of heart and kidney xenotransplants have hindered public acceptance and trust in xenotransplantation.This highlights the need to address the challenges associated with this novel approach for treating end-stage organ disease.It is important not to forget that many current medical technologies and advanced treatments were established after overcoming similar challenges and conducting rigorous safety trials.These clinical challenges are not a disappointment but are essential for future medical advancements.For instance, Transcatheter Aortic Valve Replacement (TAVR) and Thoracic Endovascular Aortic Repair (TEVAR) have become standard alternatives to traditional cardiac and vascular surgery.These procedures started with elderly, high-risk patients and are still being developed to expand their application to younger patients.
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Noda et al. (2024) studied this question.
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