Assessment of Comparative Efficacy of Shephali dal kwath (Nyctanthus arbor-tristis), Gomutra ark (Distillate of cow urine) with Erand sneha (Ricinus communis) and Erand sneha (Ricinus communis) only in the Management of Grudhrasi (Sciatica): Study Protocol (Preprint)

BACKGROUND Grudhrasi the name itself indicates the gait of a patient due to extreme pain, just like a vulture (Gidhha). It is one of the major causes of illness in developing countries like India, with variable prevalence ranging from 2% to 40%. As there is no complete cure for the disease available to date, symptoms and disease moderation are the choice of treatment. The long-term use of anti-inflammatory drugs, analgesics, and steroids has been proven to have many adverse effects. This study aimed to provide a better, easier, and affordable treatment through Ayurveda. OBJECTIVE To compare the efficacy of above three formulations namely Shephali Dal Kwath (Nyctanthes arbor-tristis) orally, Gomutra Ark (Distillate of cow urine) with Erand Sneha (Ricinus communis) orally and Erand Sneha (Ricinus communis) orally in the management of Grudhrasi (Sciatica). METHODS Patients aged–20-50 years with clinical signs and symptoms of Grudhrasi and not taking any obvious medication for the same will be included in the study with their written consent. Patients will be divided into three groups and will be treated with Shephali dal kwath (Nyctanthus arbor-tristis), Gomutra ark (Distillate of cow urine) with Erand sneha (Ricinus communis) or Erand sneha (Ricinus communis) individually. RESULTS Collected data will be recorded and analyzed with the statistical software STATA version 10.1 (2012). Statistical analysis will be performed using the Wilcoxon signed-rank test, paired t-test, and ANOVA test. CONCLUSIONS Long-term use of analgesics and other medications seems dangerous to health. Shephali dal kwath, Erand sneha and Gomutra ark have significant effects on Grudhrasi. This study was an attempt to choose a better combination according to the condition of the patient and the disease (Rog and Rogi awastha). CLINICALTRIAL Name of Registry: Clinical Trials Registry - India (CTRI) Registration Number: CTRI NO: CTRI/2022/10/046170 Registration Date: 4-Oct-2022 URL of trial in the registry database: https://ctri.nic.in/Clinicaltrials/pdf_generate.php?trialid=73472&EncHid=28711.83340&modid=1&compid=19%27,%2773472det%27