June 18, 2024PharmaceuticalsOpen Access

Assessment of Brain-Derived Neurotrophic Factor on Retinal Structure and Visual Function in Rodent Models of Optic Nerve Crush

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Authors

TTTakazumi TaniguchiSanten (Japan)NSNajam A. SharifCreighton University TOTakashi OtaSanten (Japan)

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Implication

Preclinical evaluation reveals enhanced retinal ganglion cell survival in rodent optic nerve crush models, highlighting preserved cellular structure without recovery of visual function.

Key Points

Retinal ganglion cell soma survival significantly increased after brain-derived neurotrophic factor administration in injured eyes, yet visual function remained impaired across all animals.
Optical coherence tomography quantified ganglion cell complex thickness on Day 15 following optic nerve crush, revealing moderately thicker axonal bundles across both rodent species.
Preclinical evidence supports brain-derived neurotrophic factor as a positive control in optic nerve crush studies—rodent model; further preclinical work needed to restore visual function.

Cite This Study

Taniguchi et al. (2024) studied this question.

synapsesocial.com/papers/68e643e3b6db6435875d54c9 https://doi.org/10.3390/ph17060798

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Implication

Preclinical evaluation reveals enhanced retinal ganglion cell survival in rodent optic nerve crush models, highlighting preserved cellular structure without recovery of visual function.

Assessment of Brain-Derived Neurotrophic Factor on Retinal Structure and Visual Function in Rodent Models of Optic Nerve Crush

Discussion

Member takes

Implication

Key Points

Cite This Study

Assessment of Brain-Derived Neurotrophic Factor on Retinal Structure and Visual Function in Rodent Models of Optic Nerve Crush

Discussion

Member takes

Implication

Key Points

Cite This Study

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