An episode of psychotic depression in the setting of congenital corpus callosum agenesis: A case report

Corpus callosum agenesis (ACC) is a rare congenital condition that presents heterogeneously. Growing data have showcased incidental findings of ACC following neuropsychiatric presentations. A widow in her sixties presented with an episode of self-harm. The event occurred during a depressive episode with psychotic symptoms and was precipitated by bereavement. Leading up to the presentation and weeks thereafter, family and acute mental health unit staff reported abnormal behaviours, social isolation, urinary incontinence, and self-neglect. General systemic and neurological examination was within normal limits. Cognitive examination revealed deficits primarily in executive function, fluency, and visuospatial function. Magnetic Resonance Imaging of the brain revealed complete corpus callosum agenesis. After inpatient multidisciplinary treatment, her depressive and psychotic symptoms resolved, and the patient returned to premorbid functioning. The implication of corpus callosum agenesis in the development and manifestation of neuropsychiatric manifestations is discussed following literature review.