The antipsychotic drug Clozapine is widely recognized for its efficacy in treating resistant schizophrenia. This study aims to elucidate the binding interactions of Clozapine with four key proteins: 1GQ1, 1MKF, 4OAJ, and 7WU2. These proteins represent diverse biological targets, including receptors and enzymes relevant to neurological function and drug metabolism. Utilizing molecular docking simulations, we compared the binding affinities and interaction profiles of Clozapine with these proteins.
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Chavan et al. (2024) studied this question.
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