As the fine chemical raw material, resorcinol is widely used in pharmaceuticals, rubber, plastics, dyestuffs and other fields. In Chinese medicine field, resorcinol is currently only used as an API in compounded topical preparations, with fewer applications in other areas. At present, the main industrial methods for synthesizing resorcinol are benzene sulfonation alkaline dissolution method and m-diisopropylbenzene oxidation method, which have advantages such as high yield and few by-products. However, it also has the disadvantages of harsh reaction conditions and chemical pollution. Therefore, how to design a simpler, greener and more environmentally friendly synthetic method to make up for the shortcomings has become a hot research topic at present. With the study of synthetic methods for resorcinol, resorcinolamine hydrolysis, m-dichlorobenzene hydrolysis, copper sulfate hydrolysis, m-dibenzoic acid oxidation, aromatization, phenol hydroxylation, etc. could also be used for the industrial synthesis of resorcinol. This paper outlines the current process synthesis methods of resorcinol, and summarizes and prospects the research progress of in our country.
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Li et al. (2024) studied this question.
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