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June 17, 2024Cell ReportsOpen Access

The PP2A regulatory subunit PPP2R2A controls NAD+ biosynthesis to regulate T cell subset differentiation in systemic autoimmunity

Wenliang Pan Maria Tsokos Marc Scherlinger Wei Li George C Tsokos

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Abstract

The protein phosphatase 2A (PP2A) regulatory subunit PPP2R2A is involved in the regulation of immune response. We report that lupus-prone mice with T cells deficient in PPP2R2A display less autoimmunity and nephritis. PPP2R2A deficiency promotes NAD

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Cite This Study

Pan et al. (2024) studied this question.

synapsesocial.com/papers/68e64677b6db6435875d7911 https://doi.org/10.1016/j.celrep.2024.114379

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