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Introduction: Nicotine is an agonist of the nicotinic subtype of acetylcholinergic receptors, with a half-life of two hours.Approximately 25% of the nicotine inhaled during smoking reaches the bloodstream, through which it reaches the brain within 15 seconds.It is believed to produce positive reinforcement by activating the dopaminergic pathway and the limbic system (PLANETA. 2005).Objective: Review the clinical and management of smoking abstinence.Result: Behavioral therapy is the most widely accepted and proven psychological therapy for smoking.Replacement therapies use a short maintenance period of 6 to 12 weeks, often followed by a gradual reduction period of another 6 to 12 weeks (SILVEIRA, 2021).Conclusion: All nicotine replacement therapies double cessation rates, supposedly because they reduce withdrawal (SILVEIRA, 2021).
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Goiz et al. (2024) studied this question.
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