Experimental methodology demonstrates switchable site-selective benzanilide bromination using promoter regulation, highlighting viable late-stage diversification of bioactive compounds.
Regioselective benzanilide bromination that generates either regioisomer from the same starting material is desirable. Herein, we develop switchable site-selective C(sp2)-H bromination by promoter regulation. This protocol leads to regiodivergent brominated benzanilide starting from the single substrate via selection of promoters. The protocol demonstrates excellent regioselectivity and good tolerance of functional groups with high yields. The utility effectiveness of this method has been well exemplified in the late-stage modification of biologically important molecules.
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Sun et al. (2024) studied this question.
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