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June 15, 2024Journal of EthnopharmacologyOpen Access

Inhibition of endoplasmic reticulum stress and excessive autophagy by Jiedu Tongluo Tiaogan Formula via a CaMKKβ/AMPK pathway contributes to protect pancreatic β-cells

Qi Zhang Wenqi Jin Han Wang Cheng Tang Xiaohua Zhao Yu Wang Liwei Sun Chunli Piao

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Abstract

Jiedu Tongluo Tiaogan Formula (JTTF), a traditional Chinese herbal decoction, exhibits the potential to treat type 2 diabetes mellitus (T2DM) by inhibiting endoplasmic reticulum stress (ERS) and excessive autophagy, which are the risk factors for the abnormal development and progression of β cells.

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Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e64892b6db6435875da26e https://doi.org/10.1016/j.jep.2024.118440

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Jiedu Tongluo Tiaogan Formula Modulates Glycolipid Metabolism in Type 2 Diabetes via Pyroptosis: Network Pharmacology and In Vivo Analysispreclinical · 2025 · 1 citations
2Efficacy and mechanism of Jiedu Tongluo Tiaogan Formula in treating type 2 diabetes mellitus combined with non-alcoholic fatty liver disease: Study protocol for a parallel-armed, randomized controlled trialHuman Clinical Trial · 2022 · 2 citations
3Jie-Du-Tong-Luo formula protects C2C12 myotubes against high glucose and palmitic acid injury by activating the PI3K/Akt/PPARγ pathway in vitro2024 · 1 citations
4Bioinformatic analysis and construction of competitive endogenous RNA network reveals protective effect of Jiangtang Sanhao Formula on the liver of diabetic mice2024
550-PUB: Research on the Effect of an Antidiabetic Herbal Formula by Restoring the Islet Microenvironment and Cellular Function in Type 2 Diabetes MellitusOriginal Research · 2026

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Liver Lipidomics Analysis Revealed the Protective mechanism of Zuogui Jiangtang Qinggan Formula in type 2 diabetes mellitus with non-alcoholic fatty liver disease2024
Effect and Mechanism of Qihua Tongtiao Formula (QHTTF) on Improving Glucose and Lipid Metabolism Disorders in ZDF Rats by Integrating Network Pharmacology, Metabolomics, and Biological Validation2025

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