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September 12, 2025PharmaceuticalsOpen Access

Effect and Mechanism of Qihua Tongtiao Formula (QHTTF) on Improving Glucose and Lipid Metabolism Disorders in ZDF Rats by Integrating Network Pharmacology, Metabolomics, and Biological Validation

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Authors

YJYuhua JiangHYHong YuYPYajing Pan

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Overview

This research demonstrates the effects of Qihua Tongtiao Formula on glucose and lipid metabolism in ZDF rats, highlighting its therapeutic mechanisms.

Key Points

  • Qihua Tongtiao Formula significantly improved glucose and lipid metabolism in ZDF rats, reducing insulin resistance and preventing inflammation.
  • Animal experiments showed that QHTTF lowered blood glucose and lipid levels while enhancing key proteins like PPARα and PPARγ.
  • Metabolomics identified crucial metabolic pathways affected by QHTTF, including fatty acid biosynthesis and linoleic acid metabolism.
  • Network pharmacology analysis revealed 59 targets were involved in improving glycolipid metabolic disorders in type 2 diabetes.

Cite This Study

Jiang et al. (2025) studied this question.

synapsesocial.com/papers/68d44c4631b076d99fa55a9bhttps://doi.org/10.3390/ph18091347
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