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November 11, 2025Frontiers in EndocrinologyOpen Access

Multi level effects of Sanghuang Tongxie Formula on type 2 diabetes rats: a comprehensive analysis from intestinal bacteria to metabolome and transcriptome

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Authors

JLJiaxuan LiuSBSufen BaiSBSufen Bai

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Overview

This analysis reveals Sanghuang Tongxie Formula improves insulin sensitivity and alters gut microbiota in type 2 diabetes, indicating its therapeutic efficacy.

Key Points

  • Evaluate the therapeutic efficacy of Sanghuang Tongxie Formula in a rat model of type 2 diabetes and examine the underlying mechanisms.
  • Established T2DM model in Sprague-Dawley rats using a high-fat diet and streptozotocin injection.
  • Analyzed gut microbiota composition through high-throughput sequencing and metabolic pathways via metabolomics.
  • Evaluated gene expression profiles using transcriptomics.
  • Sanghuang Tongxie Formula modified gut microbiota, increasing Bacteroidetes and decreasing Firmicutes, enhancing insulin sensitivity.
  • Metabolomics indicated changes in glycerophospholipid metabolic pathways and key metabolites due to treatment.
  • Gene expression analysis revealed alterations in Plin2 and PLD1 associated with glycerophospholipid metabolism.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/69252e96c0ce034ddc3562a2https://doi.org/10.3389/fendo.2025.1562105
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