Antihyperglycemic Effects of Active Fraction of Ethanol Extract from Castanopsis costata Leaves and Channa striata Extract on Rats

Anti-hyperglycemic experiments were conducted on male Wistar rats divided into six groups: Group 1 (negative control), Group 2 (active fraction of Castanopsis costata ethanol extract at 200 mg/kg body weight), Group 3 (Channa striata extract at 250 mg/kg body weight), Group 4 (active fraction of Castanopsis costata ethanol extract at 50 mg/kg body weight + Channa striata extract at 250 mg/kg body weight), Group 5 (active fraction of Castanopsis costata ethanol extract at 100 mg/kg body weight + Channa striata extract at 250 mg/kg body weight), and Group 6 (active fraction of Castanopsis costata ethanol extract at 200 mg/kg body weight + Channa striata extract at 250 mg/kg body weight). The most notable reduction in blood glucose levels was observed in Group 4, with an average decrease of -55.40%, followed by Group 6 (-55.19%), Group 5 (-52.80%), Group 2 (-52.01%), and Group 3 (-52.88%). These findings indicate that combining the active fraction of Castanopsis costata ethanol extract with Channa striata extract effectively lowers blood glucose levels in Wistar rats.