Sexual Behaviour of the Intact Rat Males Under the Condition of Exogenous Cholecalciferol Intake

The investigation of the impact of different doses of vitamin D3 on the sexual behaviour is the solving current problem of sexual function disorders in men and discovering the new data about vitamin D3 properties. The aim of this work was to study the altering of sexual behaviour of intact rats’ males under the condition of exogenous intake of different doses (1000 IU, 4000 IU, 10000 IU) of vitamin D3.. Materials and methods. The sexual behaviour has been studied according to the standard method in sexually active 7-month-old Wistar rats’ males with average weight of 250-300 g, on the 58th day of the introduction of vitamin D3. The solution of vitamin D3 has been introduced in volume of 0,5 ml in the doses of 1000 IU (Vit. D3-1000 group), 4000 IU (Vit. D3-4000 group) and 10000 IU (Vit. D3-10000 group). Control group of animals has received Apricot kernel oil as a solvent. The significant of differences between mean has been evaluated by Student t-test. The differences were considered to be significant at p<0.05. χ2 criterion was used for comparative analysis of relative values. Results. Exogenous long-term supplementation of vitamin D3 in dose of 1000 IU to rats hasn’t impacted the males᾿ sexual behaviour. The introduction of 4000 IU of vitamin D3 has led to increase the contacts between males and females by 50% and the number of mountings by 2.3 times to compare to Control group (р<0.05). This indicates the altering of males sexual behaviour which is regulated at central level. The signs of sexual behaviour regulated at central level have been detected in group of rats received 10000 IU of cholecalciferol: the declining of the contacts between males and females by 1.5 times (р<0.05) and increasing of mountings number by 2.1 times (р<0.05) in compare to Control group have been observed. The changing of sexual behaviour regulated at peripheral level have been detected: the latent period of intromissions was shorter by 2.1 times (р<0.05) and their number has increased. Conclusion. Exogenous long-term supplementation of vitamin D3 in dose of 1000 IU to rats hasn’t impacted the males᾿ sexual behaviour, the mating indices have increased when vitamin D in dose of 4000 IU was used, the changes of all researched indices have been observed when vitamin D3 in dose of 10000 IU was introduced.