An Extremely Rare Association Between Primary Ileal Diffuse Large B Cell Lymphoma and Carcinoid Tumor.

Introduction: The incidence of synchronous multiple primary malignancies, though rare, is increasing due to advancements in cancer therapy and screening protocols. Here, we present a case of a 50-year-old male with appendiceal carcinoid tumor and ileal diffuse large B-cell lymphoma. A 50-year-old male pr Case Report: esented with severe abdominal pain, nausea, weight loss, and anaemia. CT scan revealed a circumferential thickening in the terminal ileum with a polypoidal extension and a retroperitoneal mass. Emergency surgery revealed a large tumor involving the ileum and a mesenteric mass. Histology conrmed Diffuse Large B-cell Lymphoma in the ileum and Carcinoid in the appendix. Discussion: Primary GI non-Hodgkin lymphoma is rare, often overshadowed by secondary metastases. Carcinoid tumors, increasing in incidence, seldom associate with lymphoreticular cancers. Patients with carcinoids have high rates of second primary malignancies, challenging management. The aetiology thology remains unclear, possibly involving neuroendocrine peptides and shared signalling molecules with lymphoreticular tumors. Our article demonstrated an u Conclusion: nusual association between DLBCL and an appendiceal carcinoids that highlights the signicant role of histological and immunohistochemical staining in conrming the diagnosis.