Guizhitongluo Tablet inhibits atherosclerosis and foam cell formation through regulating Piezo1/NLRP3 mediated macrophage pyroptosis

Xianmei Pan; Honglin Xu; Zhiqiang Ding; Shangfei Luo; Zhifang Li; Rentao Wan; Jintao Jiang; Xiaoting Chen; Silin Liu; Zixin Chen; Xin Chen; Bin He; Mengting Deng; Zhu Xi; Shaoxiang Xian; Jing Li; Lingjun Wang; Hongcheng Fang

doi:10.1016/j.phymed.2024.155827

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Abstract

Atherosclerosis (AS) is the main pathological basis for the development of cardiovascular diseases. Vascular inflammation is an important factor in the formation of AS, and macrophage pyroptosis plays a key role in AS due to its unique inflammatory response. Guizhitongluo Tablet (GZTLT) has shown clinically effective in treating patients with AS, but its mechanism is elusive.

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Pan et al. (2024) studied this question.

synapsesocial.com/papers/68e64b22b6db6435875db548 https://doi.org/10.1016/j.phymed.2024.155827

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Guizhitongluo Tablet inhibits atherosclerosis and foam cell formation through regulating Piezo1/NLRP3 mediated macrophage pyroptosis

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Abstract

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Guizhitongluo Tablet inhibits atherosclerosis and foam cell formation through regulating Piezo1/NLRP3 mediated macrophage pyroptosis

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Abstract

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