Tongxinluo attenuates atherosclerosis by inhibiting ROS/NLRP3/caspase-1-mediated endothelial cell pyroptosis

Xuejiao Jiang; Chongyang Ma; Yanbin Gao; Hehe Cui; Yalin Zheng; Jinxia Li; Wenjing Zong; Qiuyun Zhang

doi:10.1016/j.jep.2022.116011

December 15, 2022Journal of EthnopharmacologyOpen Access

Tongxinluo attenuates atherosclerosis by inhibiting ROS/NLRP3/caspase-1-mediated endothelial cell pyroptosis

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Graphical abstract published by Journal of Ethnopharmacology — Graphical abstract · Published by Journal of Ethnopharmacology · CC BY-NC-ND 4.0

Why the study?

Does Tongxinluo attenuate atherosclerosis by inhibiting endothelial cell pyroptosis?

Key Points

To investigate whether Tongxinluo attenuates atherosclerosis through the suppression of ROS/NLRP3/caspase-1-mediated endothelial cell pyroptosis.
Assessed the effects of Tongxinluo administration on endothelial cell pyroptosis in an atherosclerosis model.
Evaluated changes in reactive oxygen species accumulation as a potential mediator of atherosclerosis inhibition.
Tongxinluo inhibited endothelial cell pyroptosis in the setting of atherosclerosis.
Reduction of reactive oxygen species accumulation was identified as an essential mechanism underlying atherosclerosis inhibition by Tongxinluo.

Structured PICO

Does Tongxinluo attenuate atherosclerosis by inhibiting endothelial cell pyroptosis?

P

Population

Endothelial cells in atherosclerosis

I

Intervention

Tongxinluo (TXL)

O

Outcome

Endothelial cell pyroptosis and atherosclerosis attenuationsurrogate

Tongxinluo attenuates atherosclerosis by inhibiting ROS/NLRP3/caspase-1-mediated endothelial cell pyroptosis.

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Implication

Animal data support mechanistic research on Tongxinluo; leaves open any role in human atherosclerosis.

Abstract

Our results indicated that TXL inhibited EC pyroptosis in AS. Reducing the accumulation of ROS may be the essential mechanism of AS inhibition by TXL.

Discussion

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Cite This Study

Jiang et al. (2022) studied this question.

synapsesocial.com/papers/69d809acfc5937d393ae2b27 https://doi.org/10.1016/j.jep.2022.116011

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Tongxinluo attenuates atherosclerosis by inhibiting ROS/NLRP3/caspase-1-mediated endothelial cell pyroptosis

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Tongxinluo attenuates atherosclerosis by inhibiting ROS/NLRP3/caspase-1-mediated endothelial cell pyroptosis

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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