Why the study?
Does Tongxinluo inhibit inflammatory angiogenesis and stabilize atherosclerotic plaques in apoE-/- mice?
Population
Apolipoprotein E-deficient mice fed a high-fat diet for 20 weeks, and human umbilical vein endothelial cells
Comparison
Tongxinluo at low, medium, and high doses for 16… vs Control (equal volume of buffer)
Design
Preclinical
Follow-up
16 weeks
Key result
Tongxinluo dose-dependently reduced vasa vasorum neovascularization and plaque area in apoE−/− mice by inhibiting inflammatory angiogenesis via Bmx/NF-κB/MAPK pathways.
Authors
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Hypothesis-generating for Tongxinluo in atherosclerosis; leaves open clinical translation of pathway inhibition.
Does Tongxinluo inhibit inflammatory angiogenesis and stabilize atherosclerotic plaques in apoE-/- mice?
Tongxinluo inhibits vasa vasorum proliferation and atherosclerosis progression in apoE-/- mice, likely by inhibiting inflammatory angiogenesis via Bmx/NF-κB/MAPK pathways.
Ma et al. (2015) studied Atherosclerosis. Tongxinluo (TXL) vs. equal volume of buffer was evaluated on Vasa vasorum neovascularization and plaque area. Tongxinluo dose-dependently reduced vasa vasorum neovascularization and plaque area in apoE−/− mice by inhibiting inflammatory angiogenesis via Bmx/NF-κB/MAPK pathways.