Why the study?
This study aimed to elucidate the chemical composition of Tongxinluo capsules and uncover their potential mechanisms against atherosclerosis.
Does Tongxinluo capsule extract reduce inflammation, oxidative stress, and endothelial dysfunction in preclinical models of atherosclerosis?
Population
LPS-induced RAW 264.7 cells and human endothelial EA.hy926 cells
Comparison
Tongxinluo capsule extract vs untreated or vehicle controls
Design
In vitro and network pharmacology study
Key result
Tongxinluo capsule dose-dependently reduced inflammation and oxidative stress in cell models, restoring endothelial survival and function via modulation of the NF-κB pathway and Nrf2-HO-1 axis.
Authors
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TXL targets mapped preclinically; leaves open any clinical role in atherosclerosis pending trials.
Does Tongxinluo capsule extract reduce inflammation, oxidative stress, and endothelial dysfunction in preclinical models of atherosclerosis?
Tongxinluo capsule demonstrates anti-inflammatory and antioxidant effects in vitro, supporting its potential mechanism as an adjunctive therapy for atherosclerosis.
Liu et al. (2026) studied Atherosclerosis. Tongxinluo (TXL) capsule was evaluated on Inflammation, oxidative stress, and endothelial dysfunction markers. Tongxinluo capsule dose-dependently reduced inflammation and oxidative stress in cell models, restoring endothelial survival and function via modulation of the NF-κB pathway and Nrf2-HO-1 axis.
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