Observational analysis finds lower birth weight linked to elevated plasma interferon-alpha in systemic lupus erythematosus pregnancy, highlighting its potential value as a prognostic biomarker.
Adverse pregnancy outcomes are more common in women with systemic lupus erythematosus (SLE) compared with healthy women, but we lack prognostic biomarkers. Plasma interferon alpha (IFNα) protein levels are elevated in a subgroup of pregnant women with SLE, but whether this is associated with pregnancy outcomes is unknown. We investigated the relationship between IFNα, adverse pregnancy outcomes and the presence of autoantibodies in SLE pregnancy.
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Stockfelt et al. (2024) studied this question.
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