June 14, 2024Diabetes

1218-P: A Critique of Defective Insulin Secretion and Insulin Sensitivity as a Precision Approach to Gestational Diabetes

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Authors

DJDanielle JonesAllen Institute for Brain Science LKLaura C. KusinskiUniversity of Cambridge CMCLAIRE L. MEEKUniversity of Leicester

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Implication

Observational analysis finds that physiological subtyping fails to predict adverse outcomes in pregnant women, highlighting an isolated postprandial defect.

Key Points

Precision subtyping based on insulin secretion and insulin resistance does not predict pregnancy outcomes, but it identifies a unique postprandial defect.
Among 1308 pregnant women, 71 individuals with gestational diabetes exhibited normal fasting indices alongside marked post-load hyperglycaemia.
Highlights that fasting metrics cannot capture isolated postprandial insulin sensitivity defects, questioning the clinical utility of current precision models.

Cite This Study

Jones et al. (2024) studied this question.

synapsesocial.com/papers/68e64b41b6db6435875dc4fd https://doi.org/10.2337/db24-1218-p

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Implication

Observational analysis finds that physiological subtyping fails to predict adverse outcomes in pregnant women, highlighting an isolated postprandial defect.

1218-P: A Critique of Defective Insulin Secretion and Insulin Sensitivity as a Precision Approach to Gestational Diabetes

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Cite This Study

1218-P: A Critique of Defective Insulin Secretion and Insulin Sensitivity as a Precision Approach to Gestational Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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