June 14, 2024Diabetes

1681-P: Metabolomic Signatures of Adiposity in Young Adults with Type 1 Diabetes

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Authors

DID. IgudesmanUniversity of North Carolina at Chapel Hill ECElvis Á. CarneroTranslational Research Institute ACANNA CASUTranslational Research Institute for Metabolism and Diabetes

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Implication

Matched case-control analysis demonstrates distinct metabolomic and fat distribution patterns in young adults with type 1 diabetes, highlighting lipid biomarkers of gynoid adiposity.

Key Points

Young adults with type 1 diabetes exhibit altered lipid metabolism, featuring increased gynoid fat alongside elevated phosphatidylcholine synthesis.
Gynoid fat was 0.8 kg higher and daily energy expenditure was 212 kcal/d greater in 20 patients with type 1 diabetes compared with 21 controls.
Untargeted fasting metabolomics and whole-room calorimetry reveal that altered phospholipid biosynthesis correlates with peripheral adiposity.

Cite This Study

Igudesman et al. (2024) studied this question.

synapsesocial.com/papers/68e64c4eb6db6435875dd3cc https://doi.org/10.2337/db24-1681-p

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Implication

Matched case-control analysis demonstrates distinct metabolomic and fat distribution patterns in young adults with type 1 diabetes, highlighting lipid biomarkers of gynoid adiposity.

1681-P: Metabolomic Signatures of Adiposity in Young Adults with Type 1 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

1681-P: Metabolomic Signatures of Adiposity in Young Adults with Type 1 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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