1378-P: The Association between Baseline Hemoglobin A1c (A1C) and Risk of Progression from Prediabetes to Diabetes across Adult Age Groups

Introduction 5.7%) and diabetes incidence in different decades. Results: Among 3,022,169 individuals with prediabetes, 139,450 (4.6%; mean age 54.1 ± 15.8 yrs) progressed to diabetes over a mean follow up of 4.78 years. The cumulative incidence of diabetes was greatest among those with baseline A1C levels of 6.30-6.49% in both younger (20-29 yrs: 34.5%) and older adults (≥70 yrs: 19.2%). Increased A1c conferred a far greater relative risk of progression to diabetes in adults aged 20-29 and 30-39 (A1c 6.30-6.49%: HR 51.7, 95% CI 45.0-59.3 and HR 41.3, 38.8-44.0, respectively). Relative conversion rates were more modest in adults aged ≥70 years across all A1c categories (A1c 6.30-6.49%: HR 9.7, 9.3-10.1). Conclusion: Baseline A1c was a stronger predictor of conversion from prediabetes to diabetes among younger adults, suggesting that diabetes prevention efforts should consider baseline A1C and age to reduce future risk of progression. Disclosure G.S. Fazli: None. L. Lipscombe: Other Relationship; Novo Nordisk Canada Inc. D. Thiruchelvam: None. C. Kenaszchuk: None. B.R. Shah: None. C. Ke: Advisory Panel; Sanofi. Speaker's Bureau; AstraZeneca. F.M. Ali: None. L. Rosella: None. G.L. Booth: None.