1549-P: Hyperamylinemia and Its Implications on Brain Function—Amylin Deposition and Cognitive Alterations—A Cross-Sectional Study

Introduction: Hyperamylinemia, a condition characterized by elevated levels of amylin, may contribute to amyloid deposition in the brain, akin to the amyloid plaques observed in Alzheimer's disease. This cross-sectional study explores the relationship between hyperamylinemia, amylin deposition in the brain, and subsequent effects on brain function. Methodology: In this cross-sectional study, 120 subjects were divided into normoamylinemic (n=60) and hyperamylinemic (n=60) groups based on serum amylin levels. Participants received clinical evaluations, cognitive tests, and brain imaging. Brain tissues from deceased hyperamylinemic subjects were examined for amylin deposits. Statistical methods, including logistic regression and correlation matrices, analyzed the link between amylin levels, brain deposits, and cognitive function. Results: The hyperamylinemic group showed 45% more amylin deposition in memory-related brain regions than the normoamylinemic group (p0.01). Cognitive scores were 30% lower in hyperamylinemics, correlating with their amylin levels (p0.05). Amylin aggregates were found in 80% of hyperamylinemic subjects. A strong correlation (r=0.78, p0.001) was observed between hyperamylinemia, amylin brain deposits, and reduced cognitive performance. Conclusion: Hyperamylinemia is linked to amylin accumulation in the brain and cognitive impairment, suggesting its role as a risk factor for Alzheimer's-like neurodegenerative conditions. Exploring amylin's brain functions may reveal new treatments for these diseases. Future studies are needed to clarify these mechanisms and relationships. Disclosure B.K. Choudhary: None. K. Khan: None. S. Kumar: None. H.S. Sharma: None.