What question did this study set out to answer?

This study explores the relationship between glycemic status, cognitive performance, and amyloid-β levels in older adults.

May 2, 2026SHILAP Revista de lepidopterologíaOpen Access

Glycemic dysregulation and cognitive impairment in aging adults: a cross-sectional study with amyloid biomarker correlation

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Authors

RRR. RajalakshmiJSS Academy of Higher Education and Research CRC. M. RamyaJSS Academy of Higher Education and Research RNRimshia NaazJSS Academy of Higher Education and Research

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Implication

Cross-sectional study reveals the link between glycemic status and cognitive decline in elderly individuals, suggesting early interventions are crucial.

Key Points

This study explores the relationship between glycemic status, cognitive performance, and amyloid-β levels in older adults.
Cross-sectional study of 396 elderly individuals aged 51–80 years.
Participants categorized based on HbA1c levels into four glycemic groups.
Cognitive function was assessed using the Modified Mini-Mental State Examination (3MSE).
40.15% of participants exhibited cognitive impairment, with rates increasing by glycemic group: 26.97% (no diabetes), 35.92% (prediabetes), 55.03% (controlled diabetes), and 70.91% (uncontrolled diabetes; p < 0.001).
OR for cognitive impairment was approximately 6.87 for individuals with uncontrolled diabetes (p < 0.001).
Plasma Aβ levels were elevated in diabetes groups, and the Aβ 1–42/Aβ 1–40 ratio correlated positively with cognitive performance.

Cite This Study

Rajalakshmi et al. (2026) studied this question.

synapsesocial.com/papers/69f5939871405d493affeabd https://doi.org/10.3389/fragi.2026.1696711

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Implication

Cross-sectional study reveals the link between glycemic status and cognitive decline in elderly individuals, suggesting early interventions are crucial.

Glycemic dysregulation and cognitive impairment in aging adults: a cross-sectional study with amyloid biomarker correlation

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Implication

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Cite This Study

Glycemic dysregulation and cognitive impairment in aging adults: a cross-sectional study with amyloid biomarker correlation

Discussion

Member takes

Implication

Key Points

Cite This Study

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