357-OR: Association between Continuous Glucose Monitoring and Diabetes-Related Complications in Children with Type 1 Diabetes—Nationwide Cohort Study

Introduction & Objective: This study aimed to investigate the effect of continuous glucose monitoring (CGM) on diabetes-related complications in children with type 1 diabetes. Methods: From the Korean Nationwide Cohort (2016-2022), we included children (aged <19 years) with type 1 diabetes managed by intensive insulin therapy. The primary outcome included severe hypoglycemia and diabetic ketoacidosis (DKA). Adjusted hazard ratios (HRs) for primary outcomes were compared between CGM users and non-users by using Cox proportional hazard regression models. Additionally, among CGM users, the events of severe hypoglycemia and DKA were compared before and after CGM use by paired t-test. Results: A total of 3,765 children (2,313 CGM users and 1,452 non-users) were included. During the follow-up period, CGM users showed a lower risk of severe hypoglycemia (adjusted HR: 0.48, 95% confidence interval (CI): 0.29-0.79) and DKA (adjusted HR: 0.44, 95% confidence interval (CI): 0.35-0.56). Among CGM users, the events of severe hypoglycemia and DKA significantly reduced after CGM use (p<0.001 for both). Conclusion: In this nationwide cohort study, the use of CGM reduced the risk of severe hypoglycemia and DKA in children with type 1 diabetes receiving intensive insulin therapy. Disclosure J. Kim: None. S. Kim: None. S. Cho: None. R. Oh: None. J. Kim: None.