Association of Menstrual Disorders of PCOS Women with their Clinical and Hormonal Profile: A Prospective Observational Study

The aim of our study is to examine a possible association between menstrual disorders of PCOS women with their anthropometric parameters and hormonal profile. This is a prospective observational study of women diagnosed with PCOS. Phenotypic and anthropometric data were recorded for all participants. In total, 309 women with PCOS participated in the study with an average age of 24.9 years. BMI was higher in women with a cycle of more than 35 days as well as in those with amenorrhea. The findings for the waist circumference were similar, while hip circumference values were higher in those with a cycle of fewer than 26 days and the waist/hip circumference ratio was lower in those with a cycle of fewer than 26 days. Moreover, women with a cycle of fewer than 26 days and those with amenorrhea had significantly lower PRL values and higher LH. In addition, free testosterone levels were higher in participants with amenorrhea. We provide data on the kind of menstrual disorders and the different clinical and hormonal profiles of patients. Women with a lower waist/hip ratio revealed shorter cycles, while women with higher BMI had either cycles longer than 35 days or amenorrhea. Sex hormones were also affected in women with menstrual disorders, especially in those with amenorrhea or a cycle duration of fewer than 26 days. This research contributes to the research of the correlation between anthropometric parameters and hormonal profiles in women with Polycystic Ovary Syndrome (PCOS) and their impact on menstrual disorders.