June 13, 2024Critical Care MedicineOpen Access

The Long and Winding Road of Antipsychotics for Delirium: Straightening the Path Forward*

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Authors

SHSusan HamblinLipscomb University JDJohn W. DevlinUniversity of North Carolina at Charlotte

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Implication

Systematic review and meta-analysis finds antipsychotics do not improve outcomes in critically ill adults with delirium, highlighting adherence to restrictive clinical guidelines.

Key Points

Delirium duration, mechanical ventilation length, and overall mortality remain unaffected by the administration of antipsychotics in critically ill adults.
Across five randomized placebo-controlled trials enrolling 1750 patients, haloperidol and atypical antipsychotics produced no difference in days alive without delirium or coma.
Systematic review and meta-analysis of five trials indicates that antipsychotics do not alter patient outcomes, supporting current restrictive guideline recommendations.

Cite This Study

Hamblin et al. (2024) studied this question.

synapsesocial.com/papers/68e64e7db6db6435875defa2 https://doi.org/10.1097/ccm.0000000000006301

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Implication

Systematic review and meta-analysis finds antipsychotics do not improve outcomes in critically ill adults with delirium, highlighting adherence to restrictive clinical guidelines.

The Long and Winding Road of Antipsychotics for Delirium: Straightening the Path Forward*

Discussion

Member takes

Implication

Key Points

Cite This Study

The Long and Winding Road of Antipsychotics for Delirium: Straightening the Path Forward*

Discussion

Member takes

Implication

Key Points

Cite This Study

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