Does the Frequency and Etiology of Status Epilepticus Change During the SARS-CoV-2 Pandemic?

In the neurological spectrum of Severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) infection; there are many neurological symptoms, including delirium, loss of smell and taste, encephalopathies, stroke, epileptic seizures, and SE. 3 It has been reported that SARS-CoV-2 may cause neurological symptoms due to its neuroinvasive and neurotropic properties and that the inflammatory response (cytokine storm) related to SARS-CoV-2 infection may lead to increased circulating cytokine levels and immune cell hyperactivation, which may cause secondary organ dysfunction and a life-threatening systemic inflammatory syndrome. 4SARS-CoV-2 may trigger a systemic inflammatory response and result in stroke, epileptic seizures, and SE.Acute symptomatic seizures and SE are the most commonly reported clinical conditions related to SARS-CoV-2 infection, and the mortality rate is high (5-39%). 5Although vaccines are generally safe for patients with epilepsy, they may lead to seizures, particularly with live vaccines.Although the effects of SARS-CoV-2 vaccines on seizures are still unknown, They have rarely been observed to increase epileptic seizures. 5It was found that there was a further increase in seizures after vaccination in patients with frequent seizures. 5,6In a cross-sectional study by Özdemir et al. 6 , it was reported that SARS-CoV-2 vaccines were well tolerated in patients with epilepsy, and more seizures than normal were observed in a small group of patients.In rare cases, SE cases after SARS-CoV-2 vaccination in people without epilepsy have also been reported. 7