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June 13, 2024Open Access

Single cell multiomic analyses reveal divergent effects of DNMT3A and TET2 mutant clonal hematopoiesis in inflammatory response

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Authors

WIWazim Mohammed IsmailJFJenna FernandezMBMoritz Binder

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Cite This Study

Ismail et al. (2024) studied this question.

synapsesocial.com/papers/68e64f83b6db6435875dfd38https://doi.org/10.21203/rs.3.rs-4481664/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single-cell multiomic profiling of gene mutation, chromatin accessibility, and gene expression in TET2-mutant clonal hematopoiesis2025
  2. 2Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation2024 · 17 citations
  3. 3Retrotransposable element derepression distinguishes DNMT3A-mutant from TET2-mutant clonal haematopoiesis2026
  4. 4Human TET2-mutant clonal hematopoiesis expansion is driven by distinct inflammatory signaling responses in stem cells versus myeloid progeny.2025 · 8 citations
  5. 5Clonal hematopoiesis drives T cell dysregulation and immune remodeling revealed by GWAS-based mendelian randomization and single-cell transcriptomics2025