Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is characterized by excessive antidiuretic hormone release, leading to fluid and electrolyte imbalance. We report a case of a 72-year-old female with SIADH induced by melatonin use. She presented with confusion and hyponatremia, attributed to melatonin's ADH-stimulating effect. Treatment with sodium correction and tolvaptan resulted in clinical improvement. Melatonin-induced SIADH should be considered in patients presenting with hyponatremia while on melatonin therapy.
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Balachandran et al. (2024) studied this question.
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