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June 12, 2024Molecular Biology of the Cell

LRRC56 is an IFT cargo required for assembly of the distal dynein docking complex in Trypanosoma brucei

Serge Bonnefoy Aline Araujo Alves Eloïse Bertiaux Philippe Bastin

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Abstract

Outer dynein arms (ODAs) are responsible for ciliary beating in eukaryotes. They are assembled in the cytoplasm and shipped by intraflagellar transport (IFT) before attachment to microtubule doublets via the docking complex. The LRRC56 protein has been proposed to contribute to ODAs maturation. Mutations or deletion of the

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Bonnefoy et al. (2024) studied this question.

synapsesocial.com/papers/68e650a0b6db6435875e0b82 https://doi.org/10.1091/mbc.e23-11-0425

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