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June 11, 2024Schizophrenia ResearchOpen Access

Effects of PDE10A inhibitor MK-8189 in people with an acute episode of schizophrenia: A randomized proof-of-concept clinical trial

Yuki Mukai Robert Lupinacci Stephen R. Marder Linda Snow‐Adami Tiffini Voss Sean M. Smith Michael Egan

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Abstract

PDE10A inhibition represents a potential mechanism for treating schizophrenia. PDE10A inhibitors increase cyclic nucleotides in striatal neurons, thereby mimicking the effects of dopamine receptor D2 antagonists and D1 agonists. We evaluated the PDE10A inhibitor MK-8189 for treating schizophrenia.

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Mukai et al. (2024) studied this question.

synapsesocial.com/papers/68e6541cb6db6435875e2d21 https://doi.org/10.1016/j.schres.2024.05.019

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Phase 2b Trial of the PDE10A Inhibitor MK-8189 in People With an Acute Episode of SchizophreniaHuman Clinical Trial · 2026 · 1 citations
2Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of SchizophreniaOriginal Research · 2023 · 41 citations
3PDE1B and PDE10A as novel targets for schizophrenia: from molecular design and synthesis to therapeutic promiseClinical Trial · 2026
4PDE10A Inhibitors—Clinical Failure or Window Into Antipsychotic Drug Action?Review · 2021 · 47 citations
5Phosphodiesterase 10A levels are related to striatal function in schizophrenia: a combined positron emission tomography and functional magnetic resonance imaging studycross-sectional · 2019 · 14 citations

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A Novel PDE10A Inhibitor for Tourette Syndrome and Other Movement Disorders2024
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