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June 11, 2024Abdominal RadiologyOpen Access

Clinical impact of CEUS on non-characterizable observations and observations with intermediate probability of malignancy on CT/MRI in patients at risk for HCC

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Authors

YKYuko KonoFPFabio PiscagliaSWStephanie R. Wilson

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Overview

Randomized trial demonstrates that contrast-enhanced ultrasound clarifies indeterminate nodules in patients at risk for hepatocellular carcinoma, suggesting reduced need for biopsy.

Key Points

  • Recategorization using contrast-enhanced ultrasound altered clinical management for one-third of indeterminate liver nodules, resolving cases initially inconclusive on CT or MRI scans.
  • Management recommendations changed in 33.3% of inconclusive focal liver lesions, and 96.0% of these adjusted clinical pathways proved accurate according to reference standards.
  • Prospective international multicenter validation study indicates contrast-enhanced ultrasound resolves indeterminate findings, which may eliminate invasive biopsy procedures.

Cite This Study

Kono et al. (2024) studied this question.

synapsesocial.com/papers/68e6541cb6db6435875e2d9dhttps://doi.org/10.1007/s00261-024-04305-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contrast-enhanced US of High-Risk Indeterminate Focal Liver Observations Categorized as LR-4 or LR-M at CT/MRI2025 · 11 citations
  2. 2Correlation between CEUS LI-RADS categorization of HCC < 20 mm and clinic-pathological features2024 · 6 citations
  3. 3PERSoN4: A Multiparametric Ultrasound Model to Improve CEUS LI-RADS for HCC2026
  4. 4Application Value of CEUS LI-RADS v.2017 in Focal Liver Lesions of Patients with a High Risk for Hepatocellular Carcinoma2024
  5. 5The role of ceus in the characterization of indeterminate focal liver lesions at second-level imaging methods (INFOLIL STUDY)2025