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June 11, 2024AJP Gastrointestinal and Liver Physiology

Modulation of intracellular calcium activity in interstitial cells of Cajal by inhibitory neural pathways within the internal anal sphincter

Karen I. Hannigan Emer P. Ni Bhraonain Thomas W. Gould Kathleen D. Keef Caroline A. Cobine

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Abstract

The internal anal sphincter (IAS) functions to maintain continence. Previous studies utilizing mice with cell-specific expression of GCaMP6f revealed two distinct subtypes of intramuscular interstitial cells of Cajal (ICC-IM) with differing Ca

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Hannigan et al. (2024) studied this question.

synapsesocial.com/papers/68e6542bb6db6435875e2fe7 https://doi.org/10.1152/ajpgi.00309.2023

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Role of interstitial cells of Cajal in regulating tone and responses to enteric motor neurons in the murine pyloric sphincterOriginal Research · 2026 · 1 citations
2Ion channels in interstitial cells of Cajal as targets for neurotransmitter actionreview · 2004 · 34 citations
3Role of Interstitial Cells of Cajal in the Control of Gastric MotilityOriginal Research · 2004 · 84 citations
4Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach.In Vitro Study · 1996 · 513 citations
5The possible roles of hyperpolarization-activated cyclic nucleotide channels in regulating pacemaker activity in colonic interstitial cells of CajalOriginal Research · 2013 · 45 citations

More related papers

Interstitial cell of Cajal-like cells (ICC-LC) exhibit dynamic spontaneous activity but are not functionally innervated in mouse urethra2024
TMEM16A in smooth muscle cells acts as a pacemaker channel in the internal anal sphincter2024
Absence of Interstitial Cells of Cajal in Human Colonic Muscularis Mucosae: Implications for Mucosal Motility Control2026

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