Assessment of Lipid peroxidation and total antioxidant capacity in patients with breast carcinoma

Abstract Background: Breast cancer is a prevalent life-threatening disease worldwide. Oxidative stress has been implicated in the development and progression of various cancers, including BC. Assessing lipid peroxidation and overall antioxidant status in breast cancer offers valuable information regarding the advancement, prognosis, and effectiveness of treatment options. Methods: A total of one hundred and fifty women, categorized into three groups Normal, Benign BC, and Malignant BC cases. Patients were selected and examined in the oncology clinic, fasting blood samples were collected and measurements of Total Antioxidant Capacity (TAC), Ox-LDL, CA 15.3, and CEA were performed. Then statistical analysis was done to compare the levels of these parameters in different groups and measure the analytical performance of TAC and Ox-LDL in BC. Results: The serum level of TAC in malignant cases was significantly decreased compared to benign group, 8.3 U/ml and 16.04 U/ml (P<0.001) respectively. Healthy controls show higher levels of TAC (43.4 U/ml). The levels of Ox-LDL in BC was significantly increased in malignant cases and benign group, 3831, and 1234 pg/ml, respectively compared to normal controls (682 pg/ml) (P<0.001). CEA and CA15-3 sharply increased in BC groups compared to control group. A significant area under the curve (AUC) for TAC (0.975, P<0.001), and Ox-LDL (0.986, P<0.001) was observed in ROC curve analysis. Conclusion: The present study revealed that breast cancer patients had lower TAC and higher Ox-LDL serum levels, indicating elevated oxidative stress. Additionally, TAC and Ox-LDL levels may serve as promising monitoring parameters in BC.