Association analysis of the Ex3 VNTR polymorphism of the DRD4 dopamine receptor gene with personality traits in patients with a behavioural addiction

Abstract Results In behavioural and amphetamine addicts with a higher level of the STAI trait scale and a higher level of the Neuroticism scale, the DRD4 Ex3 s/s gene polymorphism occurred significantly more often compared to the control group with the s/s polymorphism and the l/l and s/l polymorphism. Similarly, in people addicted to behavioural and amphetamine with a higher level of the STAI trait scale and a higher level of the Neuroticism scale, the DRD4 Ex3 s/l gene polymorphism occurred significantly more frequently compared to the control group with the s/s polymorphism. Conclusions: In the presented study, we see that ad-dictions should be analysed multifactorial. We can conclude that DRD4 and its polymorphic variant influence addiction development.