Early implant site development using a combination of DFDBA and T-PRF membrane for ridge preservation: A Pilot Clinical, Radiographic, Stereomorphic and Histologic Study

Abstract Objectives/ Background The primary objective of this study is to histologically evaluate new bone formation in the time frame of 12 to 14 weeks as opposed to a generally considered 16 to 20 weeks after extraction of teeth with ridge preservation using DFDBA and T-PRF membrane and secondarily to evaluate the dimensional changes including ridge width and height at these healing points. (Clinical and biometric evaluation). Materials & method: The protocol of this study has been registered in clinical trial registry (Registration number: CTRI/2021/12/038608). With the present single arm longitudinal pilot investigation including nine patients, 6 males and 3 females aged 18 to 50 years (mean 28.25 ± 6.5) requiring teeth extraction and delayed implant placement were selected to receive atraumatic extraction followed by simultaneous ridge preservation using T-PRF and DFDBA with T-PRF as biologic membrane. Results: Baseline values concerning the investigated parameters were comparable at the stipulated healing outcome period. After 12 to 14 weeks, there was no significant difference observed in alveolar ridge dimension. DFDBA & T-PRF combination revealed significantly greater vital bone formation. Investigation revealed no residual graft particles. On confirmation of achieved bone density through CBCT analysis; all implants were successfully placed at 12 to 14 weeks. Conclusion: When practiced, alveolar ridge preservation using DFDBA & T-PRF combination favours reduction in time for biologic basis of bone healing thus facilitating early implant placement to improve patient centred outcomes.