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June 10, 2024The Journal of Infectious DiseasesOpen Access

Safety and immunogenicity of a 4-component GMMA-based Shigella vaccine in healthy European adults: Stage 1 of a randomized, controlled phase I/II clinical trial

Isabel Leroux‐Roels Cathy Maes Francesca Mancini Bart Jacobs Eleanna Sarakinou Azhar Alhatemi Jasper Joye Silvia Grappi Giulia Luna Cilio Alimamy Serry-Bangura Claudia Giorgina Vitali Pietro Ferruzzi Elisa Marchetti Francesca Necchi Rino Rappuoli Iris De Ryck Jochen Auerbach Anna Colucci Omar Rossi Valentino Conti Francesco Berlanda Scorza Ashwani Kumar Arora Francesca Micoli Audino Podda Usman Nakakana Giulia Ranzato Kishor Mariyala Sateesh Aravapalli Stefania Barbucci Rob Mulder Francesco Citiulo Emilia Cappelletti Gianmarco Gasperini Carlo Giannelli Alessandra Acquaviva Luigi Sollai Renzo Alfini Maria Grazia Aruta Laura B. Martin

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Abstract

We report data from Stage 1 of an ongoing two-staged, phase I/II randomized clinical trial (NCT05073003) with a 4-component Generalized Modules for Membrane Antigens-based vaccine against Shigella sonnei and S. flexneri 1b, 2a and 3a (altSonflex1-2-3, GSK).

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Leroux‐Roels et al. (2024) studied this question.

synapsesocial.com/papers/68e65665b6db6435875e4f29 https://doi.org/10.1093/infdis/jiae273

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